Key takeaways
- • Trial: SURMOUNT-3 (NCT04657016) — Phase 3, 579 participants over 72 weeks.
- • Drug studied: Zepbound (Tirzepatide) — FDA-approved branded product.
- • Primary endpoint: Percent change in body weight from week 12 (post 12-week lifestyle lead-in) to week 84
- • Key result: Additional 18.4% weight loss on tirzepatide vs 2.5% weight regain on placebo after lifestyle-intervention lead-in
- • Published: Nature Medicine, 2023.
Study design
SURMOUNT-3 was a phase 3 randomized controlled trial enrolling 579 participants over 72 weeks. The trial studied Zepbound (Tirzepatide) for obesity / overweight and was published in Nature Medicine in 2023.
Primary endpoint
Percent change in body weight from week 12 (post 12-week lifestyle lead-in) to week 84
Key results
| Measure | Value |
|---|---|
| Headline result | Additional 18.4% weight loss on tirzepatide vs 2.5% weight regain on placebo after lifestyle-intervention lead-in |
| Mean weight loss (highest dose arm) | 26.6% |
| Participants | 579 |
| Duration | 72 weeks |
| Phase | Phase 3 |
Citation
SURMOUNT-3. Published in Nature Medicine, 2023.
GLP1Zoom did not conduct this trial. We summarize published primary literature. For verbatim methods and full results, consult the primary publication and the ClinicalTrials.gov registry record.
Related
- Zepbound drug page — pricing, FDA status, side effects, alternatives
- All tirzepatide trials
- GLP-1 clinical trials database
Other Zepbound trials
- SURMOUNT-1 — Mean weight loss 15
- SURMOUNT-2 — Mean weight loss 12
- SURMOUNT-4 — Continued tirzepatide arm lost additional 5
Other Tirzepatide trials
- SURPASS-1 (Mounjaro) — HbA1c reduction 1
- SURPASS-2 (Mounjaro) — HbA1c reduction 2
- SURPASS-3 (Mounjaro) — HbA1c reduction 1
- SURPASS-4 (Mounjaro) — HbA1c reduction 2
Important: This trial was conducted on the FDA-approved branded product Zepbound. Compounded versions of Tirzepatide have NOT been studied in equivalent randomized controlled trials, and their efficacy and safety profile may differ.
GLP1Zoom is an affiliate-only comparator. We cite published trials; we do not conduct them. This page is informational and is not a substitute for personalized medical advice — always confirm any treatment decision with your prescribing clinician. Full disclaimer.