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By GLP1Zoom editorial board
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ConditionICD-10: R73.03
Prediabetes
Prediabetes is elevated blood sugar that has not yet reached the diabetes threshold (A1c 5.7–6.4% or fasting glucose 100–125 mg/dL). ~96 million Americans have prediabetes and 80% don't know it. The good news: with diet, exercise, and sometimes medication, progression to type 2 diabetes can be slowed or reversed entirely.
Quick answer
UpdatedPrediabetes is elevated blood glucose below the diagnostic threshold for type 2 diabetes (A1C 5.7-6.4% or fasting glucose 100-125 mg/dL). Approximately 98 million US adults have prediabetes, with ~30% progressing to T2D within 5 years without intervention. GLP-1s are not yet FDA-approved specifically for prediabetes but show evidence of reducing progression — Wegovy SELECT-trial subset analysis showed lower diabetes-incidence in obese prediabetic patients.
- US prevalence: 98 million adults (~38%)
- CDC National Diabetes Statistics 2024
- Progression risk: ~30% to T2D within 5 years
- Without lifestyle intervention
- Diagnostic criteria: A1C 5.7-6.4% OR FPG 100-125 mg/dL
- ADA Standards of Care 2024
- GLP-1 evidence: Reduced T2D incidence in obese prediabetics
- SELECT trial subgroup; not FDA-approved indication
- First-line therapy: Diabetes Prevention Program (DPP) lifestyle intervention
- 58% T2D reduction over 3 years