Zepbound weight-loss results
Zepbound produced 22.5% mean body-weight reduction in the SURMOUNT-1 pivotal trial at 72 weeks — substantially more than placebo and competitive with other approved weight-loss medications. This page details the clinical evidence, eligibility criteria, and what individual results look like in practice.
How effective is Zepbound?
Mean body-weight change at 72 weeks in the SURMOUNT-1 trial. Source: FDA prescribing information.
Zepbound−22.5%
22.5%
Placebo−2.4%
GLP-1 class ceiling (tirzepatide / SURMOUNT-1)−22.5%
22.5%
Vs placebo
+20.1 pts